Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity

Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the sole conduit for postreceptor signalin...

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Detalles Bibliográficos
Autores principales: Ma, Gary S., Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Kalogriopoulos, Nicholas, Pedram, Shabnam, Midde, Krishna, Ciaraldi, Theodore P., Henry, Robert R., Ghosh, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642855/
https://www.ncbi.nlm.nih.gov/pubmed/26378251
http://dx.doi.org/10.1091/mbc.E15-08-0553

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