Ebolavirus Evolution: Past and Present

The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time...

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Detalles Bibliográficos
Autores principales: de La Vega, Marc-Antoine, Stein, Derek, Kobinger, Gary P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642951/
https://www.ncbi.nlm.nih.gov/pubmed/26562671
http://dx.doi.org/10.1371/journal.ppat.1005221
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author de La Vega, Marc-Antoine
Stein, Derek
Kobinger, Gary P
author_facet de La Vega, Marc-Antoine
Stein, Derek
Kobinger, Gary P
author_sort de La Vega, Marc-Antoine
collection PubMed
description The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona).
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spelling pubmed-46429512015-11-18 Ebolavirus Evolution: Past and Present de La Vega, Marc-Antoine Stein, Derek Kobinger, Gary P PLoS Pathog Review The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona). Public Library of Science 2015-11-12 /pmc/articles/PMC4642951/ /pubmed/26562671 http://dx.doi.org/10.1371/journal.ppat.1005221 Text en © 2015 de La Vega et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
de La Vega, Marc-Antoine
Stein, Derek
Kobinger, Gary P
Ebolavirus Evolution: Past and Present
title Ebolavirus Evolution: Past and Present
title_full Ebolavirus Evolution: Past and Present
title_fullStr Ebolavirus Evolution: Past and Present
title_full_unstemmed Ebolavirus Evolution: Past and Present
title_short Ebolavirus Evolution: Past and Present
title_sort ebolavirus evolution: past and present
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642951/
https://www.ncbi.nlm.nih.gov/pubmed/26562671
http://dx.doi.org/10.1371/journal.ppat.1005221
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