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CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock
Intracellular circadian clocks, composed of clock genes that act in transcription-translation feedback loops, drive global rhythmic expression of the mammalian transcriptome and allow an organism to anticipate to the momentum of the day. Using a novel clock-perturbing peptide, we established a pivot...
Autores principales: | Tamaru, Teruya, Hattori, Mitsuru, Honda, Kousuke, Nakahata, Yasukazu, Sassone-Corsi, Paolo, van der Horst, Gijsbertus T. J., Ozawa, Takeaki, Takamatsu, Ken |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642984/ https://www.ncbi.nlm.nih.gov/pubmed/26562092 http://dx.doi.org/10.1371/journal.pbio.1002293 |
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