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Prolonged Subdural Infusion of Kynurenic Acid Is Associated with Dose-Dependent Myelin Damage in the Rat Spinal Cord

BACKGROUND: Kynurenic acid (KYNA) is the end stage metabolite of tryptophan produced mainly by astrocytes in the central nervous system (CNS). It has neuroprotective activities but can be elevated in the neuropsychiatric disorders. Toxic effects of KYNA in the CNS are unknown. The aim of this study...

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Detalles Bibliográficos
Autores principales:	Dabrowski, Wojciech, Kwiecien, Jacek M., Rola, Radoslaw, Klapec, Michal, Stanisz, Greg J., Kotlinska-Hasiec, Edyta, Oakden, Wendy, Janik, Rafal, Coote, Margaret, Frey, Benicio N., Turski, Waldemar A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643054/ https://www.ncbi.nlm.nih.gov/pubmed/26562835 http://dx.doi.org/10.1371/journal.pone.0142598

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