Manifestation and treatment in a cleidocranial dysplasia patient with a RUNX2 (T420I) mutation

Cleidocranial dysplasia is an autosomal dominant heritable skeletal disorder. The characteristic features of cleidocranial dysplasia (CCD) may include hypoplasia of the clavicle, delayed closure of frontanelles, late tooth eruption, and other skeletal disorders. This case report describes clinical a...

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Detalles Bibliográficos
Autores principales: Lee, Chaky, Jung, Hee-sup, Baek, Jin-A, Leem, Dae Ho, Ko, Seung-O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643116/
https://www.ncbi.nlm.nih.gov/pubmed/26594640
http://dx.doi.org/10.1186/s40902-015-0042-0
Descripción
Sumario:Cleidocranial dysplasia is an autosomal dominant heritable skeletal disorder. The characteristic features of cleidocranial dysplasia (CCD) may include hypoplasia of the clavicle, delayed closure of frontanelles, late tooth eruption, and other skeletal disorders. This case report describes clinical and radiographic manifestations at the age of 11 and 29 of a CCD patient, investigates the mutation of core-binding factor A1 (CBFA1) based on gene analysis, and illustrates successful oral reconstruction with fixed prosthesis and dental implant after the extraction of multiple teeth.

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