Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies

Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in som...

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Detalles Bibliográficos
Autores principales: Domínguez, Arturo, Bayó, Miquel, Muñoz-Rodríguez, Jesús, Bellido, Jose Antonio, Abascal-Junquera, Jose María, Hannaoui, Naim, Banús, Josep Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643176/
https://www.ncbi.nlm.nih.gov/pubmed/26568798
http://dx.doi.org/10.4111/kju.2015.56.11.785
Descripción
Sumario:Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.

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