Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies

Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in som...

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Autores principales: Domínguez, Arturo, Bayó, Miquel, Muñoz-Rodríguez, Jesús, Bellido, Jose Antonio, Abascal-Junquera, Jose María, Hannaoui, Naim, Banús, Josep Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Urological Association 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643176/
https://www.ncbi.nlm.nih.gov/pubmed/26568798
http://dx.doi.org/10.4111/kju.2015.56.11.785
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author Domínguez, Arturo
Bayó, Miquel
Muñoz-Rodríguez, Jesús
Bellido, Jose Antonio
Abascal-Junquera, Jose María
Hannaoui, Naim
Banús, Josep Maria
author_facet Domínguez, Arturo
Bayó, Miquel
Muñoz-Rodríguez, Jesús
Bellido, Jose Antonio
Abascal-Junquera, Jose María
Hannaoui, Naim
Banús, Josep Maria
author_sort Domínguez, Arturo
collection PubMed
description Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL.
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spelling pubmed-46431762015-11-14 Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies Domínguez, Arturo Bayó, Miquel Muñoz-Rodríguez, Jesús Bellido, Jose Antonio Abascal-Junquera, Jose María Hannaoui, Naim Banús, Josep Maria Korean J Urol Case Report Heterophilic antibodies are human immunoglobulins directed against various animal antigens. They can produce false-positive results in the analysis of different tumor markers, including prostate-specific antigen. This interference can lead to misdiagnosis, unnecessary tests, and overtreatment in some cases. We present herein the case of a 52-year-old man with repeated spurious elevation of prostate-specific antigen, reaching levels of 108.7 ng/mL, that were suspected to be caused by heterophilic antibodies. The interference was solved by changing the analysis technique. Real values of prostate-specific antigen were less than 1 ng/mL. The Korean Urological Association 2015-11 2015-11-03 /pmc/articles/PMC4643176/ /pubmed/26568798 http://dx.doi.org/10.4111/kju.2015.56.11.785 Text en © The Korean Urological Association, 2015 http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Domínguez, Arturo
Bayó, Miquel
Muñoz-Rodríguez, Jesús
Bellido, Jose Antonio
Abascal-Junquera, Jose María
Hannaoui, Naim
Banús, Josep Maria
Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title_full Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title_fullStr Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title_full_unstemmed Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title_short Repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: A possible interference by heterophilic antibodies
title_sort repeated spurious elevation of serum prostate-specific antigen values solved by chemiluminescence analysis: a possible interference by heterophilic antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643176/
https://www.ncbi.nlm.nih.gov/pubmed/26568798
http://dx.doi.org/10.4111/kju.2015.56.11.785
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