Cargando…

New therapeutic targets in rare genetic skeletal diseases

Introduction: Genetic skeletal diseases (GSDs) are a diverse and complex group of rare genetic conditions that affect the development and homeostasis of the skeleton. Although individually rare, as a group of related diseases, GSDs have an overall prevalence of at least 1 per 4,000 children. There a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Briggs, Michael D, Bell, Peter A, Wright, Michael J, Pirog, Katarzyna A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Informa Healthcare 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643203/ https://www.ncbi.nlm.nih.gov/pubmed/26635999 http://dx.doi.org/10.1517/21678707.2015.1083853

Ejemplares similares

The utility of mouse models to provide information regarding the pathomolecular mechanisms in human genetic skeletal diseases: The emerging role of endoplasmic reticulum stress (Review)
por: BRIGGS, MICHAEL D., et al.
Publicado: (2015)

Skeletal Dysplasias Associated with Mild Myopathy—A Clinical and Molecular Review
por: Piróg, Katarzyna A., et al.
Publicado: (2010)

Mild Myopathy Is Associated with COMP but Not MATN3 Mutations in Mouse Models of Genetic Skeletal Diseases
por: Piróg, Katarzyna A., et al.
Publicado: (2013)

New developments in chondrocyte ER stress and related diseases
por: Briggs, Michael D., et al.
Publicado: (2020)

Animal models and systems biology approaches for the functional validation of genetic determinants of skeletal diseases
por: Bell, Peter A, et al.
Publicado: (2015)

Abnormal Chondrocyte Apoptosis in the Cartilage Growth Plate is Influenced by Genetic Background and Deletion of CHOP in a Targeted Mouse Model of Pseudoachondroplasia
por: Piróg, Katarzyna A., et al.
Publicado: (2014)

Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation
por: Bell, Peter A, et al.
Publicado: (2012)

The aggrecanopathies; an evolving phenotypic spectrum of human genetic skeletal diseases
por: Gibson, Beth G., et al.
Publicado: (2016)

XBP1 signalling is essential for alleviating mutant protein aggregation in ER-stress related skeletal disease
por: Piróg, Katarzyna A., et al.
Publicado: (2019)

Emerging Potential Therapeutic Targets of Ferroptosis in Skeletal Diseases
por: Liu, Xin, et al.
Publicado: (2022)

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures
por: Bell, Peter A., et al.
Publicado: (2013)

The evolving therapeutic landscape of genetic skeletal disorders
por: Sabir, Ataf Hussain, et al.
Publicado: (2019)

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases
por: Hartley, Claire L., et al.
Publicado: (2013)

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
por: Garred, Peter, et al.
Publicado: (2021)

Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target
por: Renzini, Alessandra, et al.
Publicado: (2021)

p38 MAPKs — roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets
por: Brennan, Christopher M., et al.
Publicado: (2021)

The Skeletal Muscle Emerges as a New Disease Target in Amyotrophic Lateral Sclerosis
por: Pikatza-Menoio, Oihane, et al.
Publicado: (2021)

A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia
por: Piróg, Katarzyna A., et al.
Publicado: (2010)

A Rare Skeletal Disorder, Fibrous Dysplasia: A Review of Its Pathogenesis and Therapeutic Prospects
por: Kim, Ha-Young, et al.
Publicado: (2023)

Non-Small-Cell Lung Cancer: New Rare Targets—New Targeted Therapies—State of The Art and Future Directions
por: Stencel, Katarzyna, et al.
Publicado: (2021)

Genetics provides new individualized therapeutic targets for Parkinson’s disease
por: Garcia, Eric Joshua, et al.
Publicado: (2020)

Current Genetic Survey and Potential Gene-Targeting Therapeutics for Neuromuscular Diseases
por: Chiu, Wei, et al.
Publicado: (2020)

Emerging Targeted Therapeutics for Genetic Subtypes of Parkinsonism
por: Schneider, Susanne A., et al.
Publicado: (2020)

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle
por: Tarantino, Nancy, et al.
Publicado: (2022)

Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets
por: Bianco, Cristiana, et al.
Publicado: (2021)

Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
por: Williams, Cameron B, et al.
Publicado: (2012)

Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders
por: Davidson, Beverly L., et al.
Publicado: (2022)

Skeletal Muscle Mitochondrial Dysfunction and Oxidative Stress in Peripheral Arterial Disease: A Unifying Mechanism and Therapeutic Target
por: Kim, Kyoungrae, et al.
Publicado: (2020)

Garden of therapeutic delights: new targets in rheumatic diseases
por: Waldburger, Jean M, et al.
Publicado: (2009)

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets
por: Mosquera-Heredia, Maria I., et al.
Publicado: (2021)

Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases
por: Aoki, Yoshitsugu, et al.
Publicado: (2021)

From disease to treatment: from rare skeletal disorders to treatments for osteoporosis
por: Appelman-Dijkstra, Natasha M., et al.
Publicado: (2016)

New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc
por: Corona, C, et al.
Publicado: (2011)

Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease
por: Cuthbert, Gary A., et al.
Publicado: (2020)

Lipomas: genetic basis of common skin lesions and their occurrence in rare diseases
por: Marzyńska, Dorota, et al.
Publicado: (2023)

E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration
por: Zeng, Ruiyin, et al.
Publicado: (2022)

Skeletal Aging and Osteoporosis: Mechanisms and Therapeutics
por: Chandra, Abhishek, et al.
Publicado: (2021)

New Therapeutic Targets for Mood Disorders
por: Machado-Vieira, Rodrigo, et al.
Publicado: (2010)

MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
por: Devaux, Yvan, et al.
Publicado: (2015)

S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases
por: Kurpet, Katarzyna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9df6kh1k7gtl9m2p975mf4j780