Topology of a G-quadruplex DNA formed by C9orf72 hexanucleotide repeats associated with ALS and FTD

Abnormal expansions of an intronic hexanucleotide GGGGCC (G4C2) repeat of the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Previous studies suggested that the C9orf72 hexanucleotide repeat expansion (HRE), either as DNA or t...

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Detalles Bibliográficos
Autores principales: Zhou, Bo, Liu, Changdong, Geng, Yanyan, Zhu, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643247/
https://www.ncbi.nlm.nih.gov/pubmed/26564809
http://dx.doi.org/10.1038/srep16673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643247/
https://www.ncbi.nlm.nih.gov/pubmed/26564809
http://dx.doi.org/10.1038/srep16673

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