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Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions
The physical properties of two-dimensional (2D) extracellular matrices (ECMs) modulate cell adhesion dynamics and motility, but little is known about the roles of local microenvironmental differences in three-dimensional (3D) ECMs. Here we generate 3D collagen gels of varying matrix microarchitectur...
Autores principales: | Doyle, Andrew D., Carvajal, Nicole, Jin, Albert, Matsumoto, Kazue, Yamada, Kenneth M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643399/ https://www.ncbi.nlm.nih.gov/pubmed/26548801 http://dx.doi.org/10.1038/ncomms9720 |
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