Synthetic tools for studying the chemical biology of InsP(8)

To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural...

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Detalles Bibliográficos
Autores principales: Riley, Andrew M., Wang, Huanchen, Shears, Stephen B., L. Potter, Barry V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643724/
https://www.ncbi.nlm.nih.gov/pubmed/26153667
http://dx.doi.org/10.1039/c5cc05017k
Descripción
Sumario:To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP(8) metabolism.

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