Synthetic tools for studying the chemical biology of InsP(8)

To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural...

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Detalles Bibliográficos
Autores principales: Riley, Andrew M., Wang, Huanchen, Shears, Stephen B., L. Potter, Barry V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643724/
https://www.ncbi.nlm.nih.gov/pubmed/26153667
http://dx.doi.org/10.1039/c5cc05017k
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author Riley, Andrew M.
Wang, Huanchen
Shears, Stephen B.
L. Potter, Barry V.
author_facet Riley, Andrew M.
Wang, Huanchen
Shears, Stephen B.
L. Potter, Barry V.
author_sort Riley, Andrew M.
collection PubMed
description To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP(8) metabolism.
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spelling pubmed-46437242015-12-01 Synthetic tools for studying the chemical biology of InsP(8) Riley, Andrew M. Wang, Huanchen Shears, Stephen B. L. Potter, Barry V. Chem Commun (Camb) Chemistry To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP(8) metabolism. Royal Society of Chemistry 2015-07-23 2015-08-14 /pmc/articles/PMC4643724/ /pubmed/26153667 http://dx.doi.org/10.1039/c5cc05017k Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Riley, Andrew M.
Wang, Huanchen
Shears, Stephen B.
L. Potter, Barry V.
Synthetic tools for studying the chemical biology of InsP(8)
title Synthetic tools for studying the chemical biology of InsP(8)
title_full Synthetic tools for studying the chemical biology of InsP(8)
title_fullStr Synthetic tools for studying the chemical biology of InsP(8)
title_full_unstemmed Synthetic tools for studying the chemical biology of InsP(8)
title_short Synthetic tools for studying the chemical biology of InsP(8)
title_sort synthetic tools for studying the chemical biology of insp(8)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643724/
https://www.ncbi.nlm.nih.gov/pubmed/26153667
http://dx.doi.org/10.1039/c5cc05017k
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AT lpotterbarryv synthetictoolsforstudyingthechemicalbiologyofinsp8

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