Cargando…

Synthetic tools for studying the chemical biology of InsP(8)

To synthesise stabilised mimics of InsP(8), the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riley, Andrew M., Wang, Huanchen, Shears, Stephen B., L. Potter, Barry V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643724/ https://www.ncbi.nlm.nih.gov/pubmed/26153667 http://dx.doi.org/10.1039/c5cc05017k

Ejemplares similares

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP(5) kinase
por: Riley, Andrew M., et al.
Publicado: (2012)

Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP(7)
por: Riley, Andrew M., et al.
Publicado: (2019)

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP(5)
por: Shipton, Megan L., et al.
Publicado: (2023)

Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite
por: Calvó, Paula, et al.
Publicado: (2023)

Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP(8) induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode
por: Wang, Zhenzhen, et al.
Publicado: (2020)

Cellular Internalisation of an Inositol Phosphate Visualised by Using Fluorescent InsP(5)
por: Riley, Andrew M, et al.
Publicado: (2014)

There is no ‘Conundrum’ of InsP(6)
por: Irvine, Robin F., et al.
Publicado: (2015)

Spontaneous Channel Activity of the Inositol 1,4,5-Trisphosphate (InsP(3)) Receptor (InsP(3)R). Application of Allosteric Modeling to Calcium and InsP(3) Regulation of InsP(3)R Single-channel Gating
por: Mak, Don-On Daniel, et al.
Publicado: (2003)

Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor
por: Lin, Chun-Chi, et al.
Publicado: (2011)

InsP(3) Signaling in Apicomplexan Parasites
por: Garcia, Celia R.S., et al.
Publicado: (2017)

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP(8) Levels
por: Gu, Chunfang, et al.
Publicado: (2016)

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP(7)
por: Sahu, Soumyadip, et al.
Publicado: (2023)

Inositol 1,4,5-Trisphosphate (InsP(3)) and Calcium Interact to Increase the Dynamic Range of InsP(3) Receptor-dependent Calcium Signaling
por: Kaftan, Edward J., et al.
Publicado: (1997)

Patterns of Gene Expression in Drosophila InsP(3) Receptor Mutant Larvae Reveal a Role for InsP(3) Signaling in Carbohydrate and Energy Metabolism
por: Kumar, Satish, et al.
Publicado: (2011)

Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells.
por: Giovannucci, D R, et al.
Publicado: (2000)

InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes
por: Wang, Yiguo, et al.
Publicado: (2012)

Structural and functional conservation of key domains in InsP(3) and ryanodine receptors
por: Seo, Min-Duk, et al.
Publicado: (2012)

Mechanism of BIP-4 mediated inhibition of InsP(3)Kinase-A
por: Paraschiakos, Themistoklis, et al.
Publicado: (2021)

One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP(8) Occurs under Cytosolic Conditions
por: Kurz, Leonie, et al.
Publicado: (2023)

The inositol pyrophosphate 5-InsP(7) drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α
por: Chin, Alfred C., et al.
Publicado: (2020)

Glucagon stimulates gluconeogenesis by InsP(3)R-I mediated hepatic lipolysis
por: Perry, Rachel J., et al.
Publicado: (2020)

ITPK1 is an InsP(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis
por: Riemer, Esther, et al.
Publicado: (2021)

Selective role for superoxide in InsP(3) receptor–mediated mitochondrial dysfunction and endothelial apoptosis
por: Madesh, Muniswamy, et al.
Publicado: (2005)

Altered lipid homeostasis in Drosophila InsP(3) receptor mutants leads to obesity and hyperphagia
por: Subramanian, Manivannan, et al.
Publicado: (2013)

Spatially Defined InsP(3)-Mediated Signaling in Embryonic Stem Cell-Derived Cardiomyocytes
por: Kapoor, Nidhi, et al.
Publicado: (2014)

Phototransduction in Drosophila Is Compromised by Gal4 Expression but not by InsP(3) Receptor Knockdown or Mutation
por: Bollepalli, Murali K., et al.
Publicado: (2017)

InsP(3) receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences
por: Lur, Gyorgy, et al.
Publicado: (2011)

Mode Switching Is the Major Mechanism of Ligand Regulation of InsP(3) Receptor Calcium Release Channels
por: Ionescu, Lucian, et al.
Publicado: (2007)

The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study
por: Cui, Mengqi, et al.
Publicado: (2018)

Cryo-EM reveals ligand induced allostery underlying InsP(3)R channel gating
por: Fan, Guizhen, et al.
Publicado: (2018)

Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery
por: Wang, Huanchen, et al.
Publicado: (2014)

The Relative Contributions of cAMP and InsP(3) Pathways to Olfactory Responses in Vertebrate Olfactory Receptor Neurons and the Specificity of Odorants for Both Pathways
por: Barry, Peter H.
Publicado: (2003)

Critical role of PIP5KIγ87 in InsP(3)-mediated Ca(2+) signaling
por: Wang, Ying Jie, et al.
Publicado: (2004)

Regulation of Ca(2+) Release by InsP(3) in Single Guinea Pig Hepatocytes and Rat Purkinje Neurons
por: Ogden, David, et al.
Publicado: (1997)

Function of IRAG and the phosphorylation of the InsP(3)R-I for the NO/cGMP-dependent inhibition of platelet aggregation
por: Salb, Katharina, et al.
Publicado: (2011)

Nox4 regulates InsP(3) receptor‐dependent Ca(2+) release into mitochondria to promote cell survival
por: Beretta, Matteo, et al.
Publicado: (2020)

Junctate is a key element in calcium entry induced by activation of InsP(3) receptors and/or calcium store depletion
por: Treves, Susan, et al.
Publicado: (2004)

Complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum to enhance excretion of radioactive strontium from the body
por: Ogawa, Kazuma, et al.
Publicado: (2018)

ER-luminal [Ca(2+)] regulation of InsP(3) receptor gating mediated by an ER-luminal peripheral Ca(2+)-binding protein
por: Vais, Horia, et al.
Publicado: (2020)

Inositol hexakisphosphate kinase 1 (InsP6K1) regulates neutrophil function in innate immunity by inhibiting PtdIns(3,4,5)P3 signaling
por: Prasad, Amit, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_76avhe4905olhneuh37huu88rr