Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia

Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and is associated with a dismal long-term prognosis. FLT3 tyrosine kinase inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim...

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Autores principales: Green, Alexa S., Maciel, Thiago T., Hospital, Marie-Anne, Yin, Chae, Mazed, Fetta, Townsend, Elizabeth C., Pilorge, Sylvain, Lambert, Mireille, Paubelle, Etienne, Jacquel, Arnaud, Zylbersztejn, Florence, Decroocq, Justine, Poulain, Laury, Sujobert, Pierre, Jacque, Nathalie, Adam, Kevin, So, Jason C. C., Kosmider, Olivier, Auberger, Patrick, Hermine, Olivier, Weinstock, David M., Lacombe, Catherine, Mayeux, Patrick, Vanasse, Gary J., Leung, Anskar Y., Moura, Ivan C., Bouscary, Didier, Tamburini, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643770/
https://www.ncbi.nlm.nih.gov/pubmed/26601252
http://dx.doi.org/10.1126/sciadv.1500221

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