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Extension of the generic amyloid hypothesis to nonproteinaceous metabolite assemblies

The accumulation of amyloid fibrils is the hallmark of several major human diseases. Although the formation of these supramolecular entities has previously been associated with proteins and peptides, it was later demonstrated that even phenylalanine, a single amino acid, can form fibrils that have a...

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Detalles Bibliográficos
Autores principales: Shaham-Niv, Shira, Adler-Abramovich, Lihi, Schnaider, Lee, Gazit, Ehud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643800/
https://www.ncbi.nlm.nih.gov/pubmed/26601224
http://dx.doi.org/10.1126/sciadv.1500137