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Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention

A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact th...

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Detalles Bibliográficos
Autores principales: Imai, Toshimi, Akimoto, Tetsu, Ito, Chiharu, Masuda, Takahiro, Nagata, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644139/
https://www.ncbi.nlm.nih.gov/pubmed/26609216
http://dx.doi.org/10.4137/DTI.S31710
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author Imai, Toshimi
Akimoto, Tetsu
Ito, Chiharu
Masuda, Takahiro
Nagata, Daisuke
author_facet Imai, Toshimi
Akimoto, Tetsu
Ito, Chiharu
Masuda, Takahiro
Nagata, Daisuke
author_sort Imai, Toshimi
collection PubMed
description A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. We believe that combination treatment consisting of dapagliflozin and furosemide may produce diuretic synergy via sequential nephron blockade. The accumulation of more experience with additional cases similar to ours requires continuous and careful attention.
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spelling pubmed-46441392015-11-25 Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention Imai, Toshimi Akimoto, Tetsu Ito, Chiharu Masuda, Takahiro Nagata, Daisuke Drug Target Insights Case Report A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. We believe that combination treatment consisting of dapagliflozin and furosemide may produce diuretic synergy via sequential nephron blockade. The accumulation of more experience with additional cases similar to ours requires continuous and careful attention. Libertas Academica 2015-11-11 /pmc/articles/PMC4644139/ /pubmed/26609216 http://dx.doi.org/10.4137/DTI.S31710 Text en © 2015 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Case Report
Imai, Toshimi
Akimoto, Tetsu
Ito, Chiharu
Masuda, Takahiro
Nagata, Daisuke
Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title_full Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title_fullStr Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title_full_unstemmed Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title_short Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
title_sort management of diabetes associated with nephrotic syndrome: therapeutic potential of dapagliflozin for protracted volume retention
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644139/
https://www.ncbi.nlm.nih.gov/pubmed/26609216
http://dx.doi.org/10.4137/DTI.S31710
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