Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The prolif...

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Detalles Bibliográficos
Autores principales: Duan, Hong-Fang, Li, Xiao-Qing, Hu, Hong-Yi, Li, Yu-Chi, Cai, Zhi, Mei, Xue-Shuang, Yu, Peng, Nie, Li-Ping, Zhang, Wei, Yu, Zhen-Dong, Nie, Guo-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644213/
https://www.ncbi.nlm.nih.gov/pubmed/25809707
http://dx.doi.org/10.1007/s13277-015-3356-8
Descripción
Sumario:Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.

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