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Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma

Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The prolif...

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Autores principales: Duan, Hong-Fang, Li, Xiao-Qing, Hu, Hong-Yi, Li, Yu-Chi, Cai, Zhi, Mei, Xue-Shuang, Yu, Peng, Nie, Li-Ping, Zhang, Wei, Yu, Zhen-Dong, Nie, Guo-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644213/
https://www.ncbi.nlm.nih.gov/pubmed/25809707
http://dx.doi.org/10.1007/s13277-015-3356-8
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author Duan, Hong-Fang
Li, Xiao-Qing
Hu, Hong-Yi
Li, Yu-Chi
Cai, Zhi
Mei, Xue-Shuang
Yu, Peng
Nie, Li-Ping
Zhang, Wei
Yu, Zhen-Dong
Nie, Guo-Hui
author_facet Duan, Hong-Fang
Li, Xiao-Qing
Hu, Hong-Yi
Li, Yu-Chi
Cai, Zhi
Mei, Xue-Shuang
Yu, Peng
Nie, Li-Ping
Zhang, Wei
Yu, Zhen-Dong
Nie, Guo-Hui
author_sort Duan, Hong-Fang
collection PubMed
description Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
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spelling pubmed-46442132015-11-24 Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma Duan, Hong-Fang Li, Xiao-Qing Hu, Hong-Yi Li, Yu-Chi Cai, Zhi Mei, Xue-Shuang Yu, Peng Nie, Li-Ping Zhang, Wei Yu, Zhen-Dong Nie, Guo-Hui Tumour Biol Research Article Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC. Springer Netherlands 2015-03-26 /pmc/articles/PMC4644213/ /pubmed/25809707 http://dx.doi.org/10.1007/s13277-015-3356-8 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Research Article
Duan, Hong-Fang
Li, Xiao-Qing
Hu, Hong-Yi
Li, Yu-Chi
Cai, Zhi
Mei, Xue-Shuang
Yu, Peng
Nie, Li-Ping
Zhang, Wei
Yu, Zhen-Dong
Nie, Guo-Hui
Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title_full Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title_fullStr Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title_full_unstemmed Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title_short Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma
title_sort functional elucidation of mir-494 in the tumorigenesis of nasopharyngeal carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644213/
https://www.ncbi.nlm.nih.gov/pubmed/25809707
http://dx.doi.org/10.1007/s13277-015-3356-8
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