Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling

Cancer cells acquire pathological phenotypes through accumulation of mutations that perturb signaling networks. However, global analysis of these events is currently limited. Here, we identify six types of network-attacking mutations (NAMs), including changes in kinase and SH2 modulation, network re...

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Detalles Bibliográficos
Autores principales: Creixell, Pau, Schoof, Erwin M., Simpson, Craig D., Longden, James, Miller, Chad J., Lou, Hua Jane, Perryman, Lara, Cox, Thomas R., Zivanovic, Nevena, Palmeri, Antonio, Wesolowska-Andersen, Agata, Helmer-Citterich, Manuela, Ferkinghoff-Borg, Jesper, Itamochi, Hiroaki, Bodenmiller, Bernd, Erler, Janine T., Turk, Benjamin E., Linding, Rune
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644236/
https://www.ncbi.nlm.nih.gov/pubmed/26388441
http://dx.doi.org/10.1016/j.cell.2015.08.056

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