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Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients

Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced by numerous genetic, environmental, and lifestyle...

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Autores principales: Piryaei, Mohammad, Ghaderian, Sayyed Mohammad Hossein, Vakili, Hossein, Zaimkohan, Hooshang, Mohammadi Ghahhari, Nastaran, Mafi Golchin, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644527/
https://www.ncbi.nlm.nih.gov/pubmed/26629484
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author Piryaei, Mohammad
Ghaderian, Sayyed Mohammad Hossein
Vakili, Hossein
Zaimkohan, Hooshang
Mohammadi Ghahhari, Nastaran
Mafi Golchin, Maryam
author_facet Piryaei, Mohammad
Ghaderian, Sayyed Mohammad Hossein
Vakili, Hossein
Zaimkohan, Hooshang
Mohammadi Ghahhari, Nastaran
Mafi Golchin, Maryam
author_sort Piryaei, Mohammad
collection PubMed
description Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced by numerous genetic, environmental, and lifestyle factors, and is an important reason for mortality around the globe. In this study, a novel SNP (rs6725887) in the WD Repeat Protein 12 (WDR12) gene was selected to be examined in Iranian patients with CAD. Ninety eigth healthy controls and one hundred and one CAD patients were enrolled from Iranian population, and their clinical data were collected for further comparisons. After DNA extraction from each sample, genotypes were characterized by Taq Man probe real- time PCR assay. Statistical analyses were performed to evaluate genotype and allele frequencies and compared the values with clinical variables. Body mass index, blood pressure, fasting blood sugar, LDL, HDL, cholesterol, and triglyceride significantly differed in CAD and control groups. Genotype and allele frequencies of rs6725887 in CAD patients and controls showed no significant association in the distribution. However, clinical parameters of CAD patients like HDL, LDL, FBS, TG, DBP and SBP had significantly (P<0.05) higher levels compared to control group. The rs6725887 polymorphism is unlikely to play a key role in CAD risk in our population. Further additional samples are required for better appreciation of the influence of WDR12 SNP on CAD occurrence.
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spelling pubmed-46445272015-12-01 Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients Piryaei, Mohammad Ghaderian, Sayyed Mohammad Hossein Vakili, Hossein Zaimkohan, Hooshang Mohammadi Ghahhari, Nastaran Mafi Golchin, Maryam Int J Mol Cell Med Original Article Although genetic variants that affect susceptibility to coronary artery disease (CAD) have been greatly known, a number of these single nucleotide polymorphisms (SNPs) remain to be analyzed in populations with different ethnicities. CAD is influenced by numerous genetic, environmental, and lifestyle factors, and is an important reason for mortality around the globe. In this study, a novel SNP (rs6725887) in the WD Repeat Protein 12 (WDR12) gene was selected to be examined in Iranian patients with CAD. Ninety eigth healthy controls and one hundred and one CAD patients were enrolled from Iranian population, and their clinical data were collected for further comparisons. After DNA extraction from each sample, genotypes were characterized by Taq Man probe real- time PCR assay. Statistical analyses were performed to evaluate genotype and allele frequencies and compared the values with clinical variables. Body mass index, blood pressure, fasting blood sugar, LDL, HDL, cholesterol, and triglyceride significantly differed in CAD and control groups. Genotype and allele frequencies of rs6725887 in CAD patients and controls showed no significant association in the distribution. However, clinical parameters of CAD patients like HDL, LDL, FBS, TG, DBP and SBP had significantly (P<0.05) higher levels compared to control group. The rs6725887 polymorphism is unlikely to play a key role in CAD risk in our population. Further additional samples are required for better appreciation of the influence of WDR12 SNP on CAD occurrence. Babol University of Medical Sciences 2015 /pmc/articles/PMC4644527/ /pubmed/26629484 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Piryaei, Mohammad
Ghaderian, Sayyed Mohammad Hossein
Vakili, Hossein
Zaimkohan, Hooshang
Mohammadi Ghahhari, Nastaran
Mafi Golchin, Maryam
Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title_full Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title_fullStr Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title_full_unstemmed Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title_short Analysis of rs6725887 in the WD Repeat Protein 12 in Association with Coronary Artery Disease in Iranian Patients
title_sort analysis of rs6725887 in the wd repeat protein 12 in association with coronary artery disease in iranian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644527/
https://www.ncbi.nlm.nih.gov/pubmed/26629484
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