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Sepsis and ARDS: The Dark Side of Histones
Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanism...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644547/ https://www.ncbi.nlm.nih.gov/pubmed/26609197 http://dx.doi.org/10.1155/2015/205054 |
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author | Xu, Zhiheng Huang, Yongbo Mao, Pu Zhang, Jianrong Li, Yimin |
author_facet | Xu, Zhiheng Huang, Yongbo Mao, Pu Zhang, Jianrong Li, Yimin |
author_sort | Xu, Zhiheng |
collection | PubMed |
description | Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS). Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS. In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS. Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases. |
format | Online Article Text |
id | pubmed-4644547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46445472015-11-25 Sepsis and ARDS: The Dark Side of Histones Xu, Zhiheng Huang, Yongbo Mao, Pu Zhang, Jianrong Li, Yimin Mediators Inflamm Review Article Despite advances in management over the last several decades, sepsis and acute respiratory distress syndrome (ARDS) still remain major clinical challenges and the leading causes of death for patients in intensive care units (ICUs) due to insufficient understanding of the pathophysiological mechanisms of these diseases. However, recent studies have shown that histones, also known as chromatin-basic structure proteins, could be released into the extracellular space during severe stress and physical challenges to the body (e.g., sepsis and ARDS). Due to their cytotoxic and proinflammatory effects, extracellular histones can lead to excessive and overwhelming cell damage and death, thus contributing to the pathogenesis of both sepsis and ARDS. In addition, antihistone-based treatments (e.g., neutralizing antibodies, activated protein C, and heparin) have shown protective effects and have significantly improved the outcomes of mice suffering from sepsis and ARDS. Here, we review researches related to the pathological role of histone in context of sepsis and ARDS and evaluate the potential value of histones as biomarkers and therapeutic targets of these diseases. Hindawi Publishing Corporation 2015 2015-11-01 /pmc/articles/PMC4644547/ /pubmed/26609197 http://dx.doi.org/10.1155/2015/205054 Text en Copyright © 2015 Zhiheng Xu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Xu, Zhiheng Huang, Yongbo Mao, Pu Zhang, Jianrong Li, Yimin Sepsis and ARDS: The Dark Side of Histones |
title | Sepsis and ARDS: The Dark Side of Histones |
title_full | Sepsis and ARDS: The Dark Side of Histones |
title_fullStr | Sepsis and ARDS: The Dark Side of Histones |
title_full_unstemmed | Sepsis and ARDS: The Dark Side of Histones |
title_short | Sepsis and ARDS: The Dark Side of Histones |
title_sort | sepsis and ards: the dark side of histones |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644547/ https://www.ncbi.nlm.nih.gov/pubmed/26609197 http://dx.doi.org/10.1155/2015/205054 |
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