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Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease

PURPOSE: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findi...

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Autores principales: Choi, Han Seul, Lee, Seul Bee, Kwon, Jung Hyun, Kim, Hae Soon, Sohn, Sejung, Hong, Young Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Pediatric Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644765/
https://www.ncbi.nlm.nih.gov/pubmed/26576181
http://dx.doi.org/10.3345/kjp.2015.58.10.374
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author Choi, Han Seul
Lee, Seul Bee
Kwon, Jung Hyun
Kim, Hae Soon
Sohn, Sejung
Hong, Young Mi
author_facet Choi, Han Seul
Lee, Seul Bee
Kwon, Jung Hyun
Kim, Hae Soon
Sohn, Sejung
Hong, Young Mi
author_sort Choi, Han Seul
collection PubMed
description PURPOSE: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. METHODS: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. RESULTS: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. CONCLUSION: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count.
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spelling pubmed-46447652015-11-16 Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease Choi, Han Seul Lee, Seul Bee Kwon, Jung Hyun Kim, Hae Soon Sohn, Sejung Hong, Young Mi Korean J Pediatr Original Article PURPOSE: Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and those without uveitis. METHODS: We conducted a prospective study with 110 KD patients from January 2008 to June 2013. The study group (n=32, KD with uveitis) was compared with the control group (n=78, KD without uveitis). Laboratory data were obtained from each patient including complete blood count (CBC), erythrocyte sedimentation rate (ESR), platelet count, and level of alanine aminotransferase, aspartate aminotransferase, serum total protein, albumin, C-reactive protein (CRP), and N-terminal probrain natriuretic peptide (NT-pro BNP). Echocardiographic measurements and intravenous immunoglobulin responses were compared between the two groups. RESULTS: The incidence of uveitis was 29.0%. Neutrophil counts and patient age were higher in the uveitis group than in the control group. ESR and CRP level were slightly increased in the uveitis group compared with the control group, but the difference between the two groups was not significant. No significant differences in coronary arterial complication and treatment responses were observed between the two groups. CONCLUSION: Uveitis is an important ocular sign in the diagnosis of incomplete KD. It is significantly associated with patient age and neutrophil count. The Korean Pediatric Society 2015-10 2015-10-21 /pmc/articles/PMC4644765/ /pubmed/26576181 http://dx.doi.org/10.3345/kjp.2015.58.10.374 Text en Copyright © 2015 by The Korean Pediatric Society http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Choi, Han Seul
Lee, Seul Bee
Kwon, Jung Hyun
Kim, Hae Soon
Sohn, Sejung
Hong, Young Mi
Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title_full Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title_fullStr Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title_full_unstemmed Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title_short Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
title_sort uveitis as an important ocular sign to help early diagnosis in kawasaki disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644765/
https://www.ncbi.nlm.nih.gov/pubmed/26576181
http://dx.doi.org/10.3345/kjp.2015.58.10.374
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