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Revealing the binding modes and the unbinding of 14-3-3σ proteins and inhibitors by computational methods
The 14-3-3σ proteins are a family of ubiquitous conserved eukaryotic regulatory molecules involved in the regulation of mitogenic signal transduction, apoptotic cell death, and cell cycle control. A lot of small-molecule inhibitors have been identified for 14-3-3 protein-protein interactions (PPIs)....
Autores principales: | Hu, Guodong, Cao, Zanxia, Xu, Shicai, Wang, Wei, Wang, Jihua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644958/ https://www.ncbi.nlm.nih.gov/pubmed/26568041 http://dx.doi.org/10.1038/srep16481 |
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