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Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays

Rho-associated kinases (ROCKs) have been regarded as promising drug targets for the treatment of cardiovascular diseases, nervous system diseases and cancers. In this study, a novel integrated virtual screening protocol by combining molecular docking and pharmacophore mapping based on multiple ROCK1...

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Detalles Bibliográficos
Autores principales:	Shen, Mingyun, Tian, Sheng, Pan, Peichen, Sun, Huiyong, Li, Dan, Li, Youyong, Zhou, Hefeng, Li, Chuwen, Lee, Simon Ming-Yuen, Hou, Tingjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645114/ https://www.ncbi.nlm.nih.gov/pubmed/26568382 http://dx.doi.org/10.1038/srep16749

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