Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily

Kinase inhibitors are attractive drugs/drug candidates for the treatment of cancer. The most recent literature has highlighted the importance of multi target kinase inhibitors, although a correct balance between specificity and non-specificity is required. In this view, the discovery of multi-tyrosi...

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Detalles Bibliográficos
Autores principales: Gandin, Valentina, Ferrarese, Alessandro, Dalla Via, Martina, Marzano, Cristina, Chilin, Adriana, Marzaro, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645160/
https://www.ncbi.nlm.nih.gov/pubmed/26568452
http://dx.doi.org/10.1038/srep16750

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