Cargando…

Optimizing engineered TCR T cell therapy for synovial sarcoma

Detalles Bibliográficos
Autores principales:	D'Angelo, Sandra, Merchant, Melinda, Melchiori, Luca, Zhang, Hua, Pandite, Lini, Holdich, Tom, Binder-Scholl, Gwendolyn, Tap, William, Fortin, Marylene, Peretz, Yoav, Wright, Matthew, Meyers, Paul, Amado, Rafael, Jakobsen, Bent, Mackall, Crystal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Poster Presentation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645508/ http://dx.doi.org/10.1186/2051-1426-3-S2-P159

Ejemplares similares

Deep phenotypic characterization of NY-ESO TCR engineered T cells and tumor in patients with advanced myeloma
por: Davila, Eduardo, et al.
Publicado: (2015)

Preclinical safety testing of an affinity-optimised MAGE-A10 T cell receptor for adoptive T cell therapy
por: Gerry, Andrew, et al.
Publicado: (2015)

Process improvement and comparability analysis for engineered T cell manufacture
por: Melchiori, Luca, et al.
Publicado: (2014)

NY-ESO-1 specific TCR engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma
por: Rapoport, Aaron P., et al.
Publicado: (2015)

Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma
por: Ramachandran, Indu, et al.
Publicado: (2019)

Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma
por: Gyurdieva, Alexandra, et al.
Publicado: (2022)

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions
por: Cole, David K., et al.
Publicado: (2014)

Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT
por: Rapoport, Aaron P, et al.
Publicado: (2013)

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis
por: Rossetti, Maura, et al.
Publicado: (2017)

In Search of Targeted Therapies for Childhood Cancer
por: Mackall, Crystal L.
Publicado: (2011)

TCR‐induced alteration of primary MHC peptide anchor residue
por: Madura, Florian, et al.
Publicado: (2019)

ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing
por: Donnellan, Zoe, et al.
Publicado: (2015)

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis
por: Komech, Ekaterina A., et al.
Publicado: (2022)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity
por: Hedlund, Gunnar, et al.
Publicado: (2013)

Redox-sensitive changes in conformation and cellular localization of LAT and downstream TCR signaling lead to hyporesponsiveness of synovial fluid T cells in rheumatoid arthritis
por: Gringhuis, SI, et al.
Publicado: (2001)

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis
por: Køster, Ditte, et al.
Publicado: (2021)

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
por: Sportès, Claude, et al.
Publicado: (2008)

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression
por: Bending, David, et al.
Publicado: (2015)

Chondroitin sulfate proteoglycan 4 specific chimeric antigen receptor therapy for pediatric solid tumors
por: Tschernia, Nicholas, et al.
Publicado: (2014)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
por: Poorebrahim, Mansour, et al.
Publicado: (2021)

epiTCR: a highly sensitive predictor for TCR–peptide binding
por: Pham, My-Diem Nguyen, et al.
Publicado: (2023)

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy
por: Raman, Marine C C, et al.
Publicado: (2016)

Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System
por: Yokosuka, Tadashi, et al.
Publicado: (2002)

Risk Factors Including Age, Stage and Anatomic Location that Impact the Outcomes of Patients with Synovial Sarcoma
por: Pan, Minggui, et al.
Publicado: (2018)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

TCR chain gangs
por: Van Epps, Heather L.
Publicado: (2005)

Autoimmune TCR structure
por: LeBrasseur, Nicole
Publicado: (2005)

Far from the TCR
por: Bätz, M
Publicado: (2004)

On the Control of TCR Phosphorylation
por: Fernandes, Ricardo A., et al.
Publicado: (2012)

TCR moves to MCR
por: Peter Sollander, AB/OP/TI
Publicado: (2005)

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode
por: Cole, David K., et al.
Publicado: (2013)

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit
Publicado: (1995)

Joining Forces for Cancer Treatment: From “TCR versus CAR” to “TCR and CAR”
por: Teppert, Karin, et al.
Publicado: (2022)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain
por: Kirchgessner, Henning, et al.
Publicado: (2001)

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
por: Montemurro, Alessandro, et al.
Publicado: (2021)

Enhancing Efficacy of TCR-engineered CD4(+) T Cells Via Coexpression of CD8α
por: Anderson, Victoria E., et al.
Publicado: (2023)

The local and systemic cytokine signatures of juvenile idiopathic arthritis are attributable to tcr-independent activation of two novel subsets of prematurely senescent t cells found in synovial fluid
por: Vallejo, Abbe, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0v5cii9ajig4g2486ice02m76d