Evaluation of antimicrobial properties of bioactive glass used in regenerative periodontal therapy

CONTEXT: Bone grafting materials which have an inherent anti-microbial property against initial colonizers of plaque bacteria would be useful in regenerative periodontal surgical procedures. AIMS: This study was performed to analyze the antibacterial property of a Perioglas™ against a common oral commensal Streptococcus salivarius (early colonizer). SETTINGS AND DESIGN: In vitro observational study. MATERIALS AND METHODS: Perioglas™ (in various concentrations) was assessed for its antibacterial property against the ATCC 13419 strain of S. salivarius. The anti-microbial activity was analyzed in terms of reduction in colony-forming units in culture plates and smear following a 24 h incubation at 37°C. STATISTICAL ANALYSIS USED: Observational study - No statistical analysis applicable. RESULTS: The bioactive glass (BAG) exerted an antibacterial effect against the S. salivarius in the suspending media and smear. The antibacterial activity of BAG increased in proportion with its concentration. CONCLUSIONS: Perioglas™ demonstrated a considerable antibacterial effect against S. salivarius at 50 mg/mL concentration.