Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SI...

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Detalles Bibliográficos
Autores principales: Karsten, Christina B., Buettner, Falk F. R., Cajic, Samanta, Nehlmeier, Inga, Neumann, Berit, Klippert, Antonina, Sauermann, Ulrike, Reichl, Udo, Gerardy-Schahn, Rita, Rapp, Erdmann, Stahl-Hennig, Christiane, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645679/
https://www.ncbi.nlm.nih.gov/pubmed/26355090
http://dx.doi.org/10.1128/JVI.01358-15
Descripción
Sumario:Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SIV Env with these N-glycans reduces viral infectivity and abrogates mucosal transmission, despite increasing viral capture by immune cell lectins. Thus, high-mannose N-glycans have opposed effects on SIV infectivity and lectin reactivity, and a balance might be required for efficient mucosal transmission.

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