Genetic of Alzheimer’s Disease: A Narrative Review Article

BACKGROUND: Alzheimer’s disease (AD) is one of the most common problems for old peoples. Etiology of AD is not clear, but genetic factors play a major role in determining a person’s risk to develop AD. Twin and family studies confirm that AD has a genetic basis. AD genetics has been split into two broad categories: early-onset and late-onset. EOAD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes like APP, PSEN-1 and PSEN-2 associated with AD. This study aimed to consider the role of genetic in AD. METHOD: At the first, most of the references in relation with genetic basis of AD searched from the following web-sites: PubMed, Science direct, Wiley & Sons (1995–2014). Then, the most common genes and their affects described briefly. RESULTS: Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course this relation is not complete but it is significant. CONCLUSION: More than thousand genes studied in relation with Alzheimer’s disease. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remain unclear.