Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review

INTRODUCTION: Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal. METHODS: Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field...

Descripción completa

Detalles Bibliográficos
Autores principales: Lewis, Joseph M., Macpherson, Peter, Adams, Emily R., Ochodo, Eleanor, Sands, Anita, Taegtmeyer, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Clinical Science: Concise Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645957/
https://www.ncbi.nlm.nih.gov/pubmed/26558545
http://dx.doi.org/10.1097/QAD.0000000000000855
Descripción
Sumario:INTRODUCTION: Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal. METHODS: Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search. RESULTS: Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%. CONCLUSION: Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

Ejemplares similares