Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review

INTRODUCTION: Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal. METHODS: Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field...

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Autores principales: Lewis, Joseph M., Macpherson, Peter, Adams, Emily R., Ochodo, Eleanor, Sands, Anita, Taegtmeyer, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Clinical Science: Concise Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645957/
https://www.ncbi.nlm.nih.gov/pubmed/26558545
http://dx.doi.org/10.1097/QAD.0000000000000855
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author Lewis, Joseph M.
Macpherson, Peter
Adams, Emily R.
Ochodo, Eleanor
Sands, Anita
Taegtmeyer, Miriam
author_facet Lewis, Joseph M.
Macpherson, Peter
Adams, Emily R.
Ochodo, Eleanor
Sands, Anita
Taegtmeyer, Miriam
author_sort Lewis, Joseph M.
collection PubMed
description INTRODUCTION: Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal. METHODS: Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search. RESULTS: Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%. CONCLUSION: Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.
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spelling pubmed-46459572015-11-30 Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review Lewis, Joseph M. Macpherson, Peter Adams, Emily R. Ochodo, Eleanor Sands, Anita Taegtmeyer, Miriam AIDS Clinical Science: Concise Communications INTRODUCTION: Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal. METHODS: Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search. RESULTS: Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%. CONCLUSION: Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1. Lippincott Williams & Wilkins 2015-11-28 2015-11-18 /pmc/articles/PMC4645957/ /pubmed/26558545 http://dx.doi.org/10.1097/QAD.0000000000000855 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 2 http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Clinical Science: Concise Communications
Lewis, Joseph M.
Macpherson, Peter
Adams, Emily R.
Ochodo, Eleanor
Sands, Anita
Taegtmeyer, Miriam
Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title_full Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title_fullStr Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title_full_unstemmed Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title_short Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review
title_sort field accuracy of fourth-generation rapid diagnostic tests for acute hiv-1: a systematic review
topic Clinical Science: Concise Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645957/
https://www.ncbi.nlm.nih.gov/pubmed/26558545
http://dx.doi.org/10.1097/QAD.0000000000000855
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