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Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients
Chronic low back pain (chronic LBP) is both debilitating for patients but also a major burden on the health care system. Previous studies reported various maladaptive structural and functional changes among chronic LBP patients on spine- and supraspinal levels including behavioral alterations. Howev...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646462/ https://www.ncbi.nlm.nih.gov/pubmed/26569602 http://dx.doi.org/10.1371/journal.pone.0142391 |
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author | Vrana, Andrea Hotz-Boendermaker, Sabina Stämpfli, Philipp Hänggi, Jürgen Seifritz, Erich Humphreys, B. Kim Meier, Michael L. |
author_facet | Vrana, Andrea Hotz-Boendermaker, Sabina Stämpfli, Philipp Hänggi, Jürgen Seifritz, Erich Humphreys, B. Kim Meier, Michael L. |
author_sort | Vrana, Andrea |
collection | PubMed |
description | Chronic low back pain (chronic LBP) is both debilitating for patients but also a major burden on the health care system. Previous studies reported various maladaptive structural and functional changes among chronic LBP patients on spine- and supraspinal levels including behavioral alterations. However, evidence for cortical reorganization in the sensorimotor system of chronic LBP patients is scarce. Motor Imagery (MI) is suitable for investigating the cortical sensorimotor network as it serves as a proxy for motor execution. Our aim was to investigate differential MI-driven cortical processing in chronic LBP compared to healthy controls (HC) by means of functional magnetic resonance imaging (fMRI). Twenty-nine subjects (15 chronic LBP patients, 14 HC) were included in the current study. MI stimuli consisted of randomly presented video clips showing every-day activities involving different whole-body movements as well as walking on even ground and walking downstairs and upstairs. Guided by the video clips, subjects had to perform MI of these activities, subsequently rating the vividness of their MI performance. Brain activity analysis revealed that chronic LBP patients exhibited significantly reduced activity compared to HC subjects in MI-related brain regions, namely the left supplementary motor area and right superior temporal sulcus. Furthermore, psycho-physiological-interaction analysis yielded significantly enhanced functional connectivity (FC) between various MI-associated brain regions in chronic LBP patients indicating diffuse and non-specific changes in FC. Current results demonstrate initial findings about differences in MI-driven cortical processing in chronic LBP pointing towards reorganization processes in the sensorimotor network. |
format | Online Article Text |
id | pubmed-4646462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46464622015-11-25 Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients Vrana, Andrea Hotz-Boendermaker, Sabina Stämpfli, Philipp Hänggi, Jürgen Seifritz, Erich Humphreys, B. Kim Meier, Michael L. PLoS One Research Article Chronic low back pain (chronic LBP) is both debilitating for patients but also a major burden on the health care system. Previous studies reported various maladaptive structural and functional changes among chronic LBP patients on spine- and supraspinal levels including behavioral alterations. However, evidence for cortical reorganization in the sensorimotor system of chronic LBP patients is scarce. Motor Imagery (MI) is suitable for investigating the cortical sensorimotor network as it serves as a proxy for motor execution. Our aim was to investigate differential MI-driven cortical processing in chronic LBP compared to healthy controls (HC) by means of functional magnetic resonance imaging (fMRI). Twenty-nine subjects (15 chronic LBP patients, 14 HC) were included in the current study. MI stimuli consisted of randomly presented video clips showing every-day activities involving different whole-body movements as well as walking on even ground and walking downstairs and upstairs. Guided by the video clips, subjects had to perform MI of these activities, subsequently rating the vividness of their MI performance. Brain activity analysis revealed that chronic LBP patients exhibited significantly reduced activity compared to HC subjects in MI-related brain regions, namely the left supplementary motor area and right superior temporal sulcus. Furthermore, psycho-physiological-interaction analysis yielded significantly enhanced functional connectivity (FC) between various MI-associated brain regions in chronic LBP patients indicating diffuse and non-specific changes in FC. Current results demonstrate initial findings about differences in MI-driven cortical processing in chronic LBP pointing towards reorganization processes in the sensorimotor network. Public Library of Science 2015-11-16 /pmc/articles/PMC4646462/ /pubmed/26569602 http://dx.doi.org/10.1371/journal.pone.0142391 Text en © 2015 Vrana et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Vrana, Andrea Hotz-Boendermaker, Sabina Stämpfli, Philipp Hänggi, Jürgen Seifritz, Erich Humphreys, B. Kim Meier, Michael L. Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title | Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title_full | Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title_fullStr | Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title_full_unstemmed | Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title_short | Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients |
title_sort | differential neural processing during motor imagery of daily activities in chronic low back pain patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646462/ https://www.ncbi.nlm.nih.gov/pubmed/26569602 http://dx.doi.org/10.1371/journal.pone.0142391 |
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