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Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway

α(1a) Adrenergic receptors (α(1a)ARs) are the predominant AR subtype in human vascular smooth muscle cells (SMCs). α(1a)ARs in resistance vessels are crucial in the control of blood pressure, yet the impact of naturally occurring human α(1a)AR genetic variants in cardiovascular disorders remains poo...

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Detalles Bibliográficos
Autores principales:	Gradinaru, Irina, Babaeva, Ekaterina, Schwinn, Debra A., Oganesian, Anush
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646490/ https://www.ncbi.nlm.nih.gov/pubmed/26571308 http://dx.doi.org/10.1371/journal.pone.0142787

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