Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways

Histone deacetylase inhibitors (HDACi) have been evaluated in patients with Ewing sarcoma (EWS) but demonstrated limited activity. To better understand the potential for HDACi in EWS, we evaluated the combination of the HDACi vorinostat, with DNA damaging agents SN-38 (the active metabolite of irino...

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Detalles Bibliográficos
Autores principales: Sampson, Valerie B., Vetter, Nancy S., Kamara, Davida F., Collier, Anderson B., Gresh, Renee C., Kolb, E. Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646493/
https://www.ncbi.nlm.nih.gov/pubmed/26571493
http://dx.doi.org/10.1371/journal.pone.0142704

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