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Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies

BACKGROUND: Studies of work disability in diabetes have examined diabetes as a homogeneous disease. We sought to identify subgroups among persons with diabetes based on potential risk factors for work disability. METHODS: Participants were 2,445 employees with diabetes from three prospective cohorts...

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Autores principales: Virtanen, Marianna, Vahtera, Jussi, Head, Jenny, Dray-Spira, Rosemary, Okuloff, Annaleena, Tabak, Adam G., Goldberg, Marcel, Ervasti, Jenni, Jokela, Markus, Singh-Manoux, Archana, Pentti, Jaana, Zins, Marie, Kivimäki, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646666/
https://www.ncbi.nlm.nih.gov/pubmed/26569491
http://dx.doi.org/10.1371/journal.pone.0143184
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author Virtanen, Marianna
Vahtera, Jussi
Head, Jenny
Dray-Spira, Rosemary
Okuloff, Annaleena
Tabak, Adam G.
Goldberg, Marcel
Ervasti, Jenni
Jokela, Markus
Singh-Manoux, Archana
Pentti, Jaana
Zins, Marie
Kivimäki, Mika
author_facet Virtanen, Marianna
Vahtera, Jussi
Head, Jenny
Dray-Spira, Rosemary
Okuloff, Annaleena
Tabak, Adam G.
Goldberg, Marcel
Ervasti, Jenni
Jokela, Markus
Singh-Manoux, Archana
Pentti, Jaana
Zins, Marie
Kivimäki, Mika
author_sort Virtanen, Marianna
collection PubMed
description BACKGROUND: Studies of work disability in diabetes have examined diabetes as a homogeneous disease. We sought to identify subgroups among persons with diabetes based on potential risk factors for work disability. METHODS: Participants were 2,445 employees with diabetes from three prospective cohorts (the Finnish Public Sector study, the GAZEL study, and the Whitehall II study). Work disability was ascertained via linkage to registers of sickness absence and disability pensions during a follow-up of 4 years. Study-specific latent class analysis was used to identify subgroups according to prevalent comorbid disease and health-risk behaviours. Study-specific associations with work disability at follow-up were pooled using fixed-effects meta-analysis. RESULTS: Separate latent class analyses for men and women in each cohort supported a two-class solution with one subgroup (total n = 1,086; 44.4%) having high prevalence of chronic somatic diseases, psychological symptoms, obesity, physical inactivity and abstinence from alcohol and the other subgroup (total n = 1,359; 55.6%) low prevalence of these factors. In the adjusted meta-analyses, participants in the ‘high-risk’ group had more work disability days (pooled rate ratio = 1.66, 95% CI 1.38–1.99) and more work disability episodes (pooled rate ratio = 1.33, 95% CI 1.21–1.46). These associations were similar in men and women, younger and older participants, and across occupational groups. CONCLUSIONS: Diabetes is not a homogeneous disease in terms of work disability risk. Approximately half of people with diabetes are assigned to a subgroup characterised by clustering of comorbid health conditions, obesity, physical inactivity, abstinence of alcohol, and associated high risk of work disability; the other half to a subgroup characterised by a more favourable risk profile.
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spelling pubmed-46466662015-11-25 Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies Virtanen, Marianna Vahtera, Jussi Head, Jenny Dray-Spira, Rosemary Okuloff, Annaleena Tabak, Adam G. Goldberg, Marcel Ervasti, Jenni Jokela, Markus Singh-Manoux, Archana Pentti, Jaana Zins, Marie Kivimäki, Mika PLoS One Research Article BACKGROUND: Studies of work disability in diabetes have examined diabetes as a homogeneous disease. We sought to identify subgroups among persons with diabetes based on potential risk factors for work disability. METHODS: Participants were 2,445 employees with diabetes from three prospective cohorts (the Finnish Public Sector study, the GAZEL study, and the Whitehall II study). Work disability was ascertained via linkage to registers of sickness absence and disability pensions during a follow-up of 4 years. Study-specific latent class analysis was used to identify subgroups according to prevalent comorbid disease and health-risk behaviours. Study-specific associations with work disability at follow-up were pooled using fixed-effects meta-analysis. RESULTS: Separate latent class analyses for men and women in each cohort supported a two-class solution with one subgroup (total n = 1,086; 44.4%) having high prevalence of chronic somatic diseases, psychological symptoms, obesity, physical inactivity and abstinence from alcohol and the other subgroup (total n = 1,359; 55.6%) low prevalence of these factors. In the adjusted meta-analyses, participants in the ‘high-risk’ group had more work disability days (pooled rate ratio = 1.66, 95% CI 1.38–1.99) and more work disability episodes (pooled rate ratio = 1.33, 95% CI 1.21–1.46). These associations were similar in men and women, younger and older participants, and across occupational groups. CONCLUSIONS: Diabetes is not a homogeneous disease in terms of work disability risk. Approximately half of people with diabetes are assigned to a subgroup characterised by clustering of comorbid health conditions, obesity, physical inactivity, abstinence of alcohol, and associated high risk of work disability; the other half to a subgroup characterised by a more favourable risk profile. Public Library of Science 2015-11-16 /pmc/articles/PMC4646666/ /pubmed/26569491 http://dx.doi.org/10.1371/journal.pone.0143184 Text en © 2015 Virtanen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Virtanen, Marianna
Vahtera, Jussi
Head, Jenny
Dray-Spira, Rosemary
Okuloff, Annaleena
Tabak, Adam G.
Goldberg, Marcel
Ervasti, Jenni
Jokela, Markus
Singh-Manoux, Archana
Pentti, Jaana
Zins, Marie
Kivimäki, Mika
Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title_full Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title_fullStr Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title_full_unstemmed Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title_short Work Disability among Employees with Diabetes: Latent Class Analysis of Risk Factors in Three Prospective Cohort Studies
title_sort work disability among employees with diabetes: latent class analysis of risk factors in three prospective cohort studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646666/
https://www.ncbi.nlm.nih.gov/pubmed/26569491
http://dx.doi.org/10.1371/journal.pone.0143184
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