Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1

The central molecular event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)), which is a sialoglycoprotein, into the disease-associated, transmissible form denoted PrP(Sc). Recent studies revealed a correlation between the sialylation status...

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Detalles Bibliográficos
Autores principales: Katorcha, Elizaveta, Klimova, Nina, Makarava, Natallia, Savtchenko, Regina, Pan, Xuefang, Annunziata, Ida, Takahashi, Kohta, Miyagi, Taeko, Pshezhetsky, Alexey V., d’Azzo, Alessandra, Baskakov, Ilia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646690/
https://www.ncbi.nlm.nih.gov/pubmed/26569607
http://dx.doi.org/10.1371/journal.pone.0143218

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