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Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

Antigen-specific immune responses to protein drugs can hinder efficacy and compromise safety because of drug neutralization and secondary clinical complications. We report a tolerance induction strategy to prevent antigen-specific humoral immune responses to therapeutic proteins. Our modular, biomol...

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Detalles Bibliográficos
Autores principales:	Lorentz, Kristen M., Kontos, Stephan, Diaceri, Giacomo, Henry, Hugues, Hubbell, Jeffrey A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646778/ https://www.ncbi.nlm.nih.gov/pubmed/26601215 http://dx.doi.org/10.1126/sciadv.1500112

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