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Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

Hypertrophic cardiomyopathy (HCM) is the most frequently occurring inherited cardiovascular disease. It is caused by mutations in genes encoding the force-generating machinery of the cardiac sarcomere, including human β-cardiac myosin. We present a detailed characterization of the most debated HCM-c...

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Detalles Bibliográficos
Autores principales:	Nag, Suman, Sommese, Ruth F., Ujfalusi, Zoltan, Combs, Ariana, Langer, Stephen, Sutton, Shirley, Leinwand, Leslie A., Geeves, Michael A., Ruppel, Kathleen M., Spudich, James A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646805/ https://www.ncbi.nlm.nih.gov/pubmed/26601291 http://dx.doi.org/10.1126/sciadv.1500511

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