Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix

Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer...

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Autores principales: Ong, Shawn Y., Taverna, Josephine, Jokerst, Clint, Enzler, Thomas, Hammode, Emad, Rogowitz, Elisa, Green, Myke R., Babiker, Hani M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646996/
https://www.ncbi.nlm.nih.gov/pubmed/26613055
http://dx.doi.org/10.1155/2015/212543
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author Ong, Shawn Y.
Taverna, Josephine
Jokerst, Clint
Enzler, Thomas
Hammode, Emad
Rogowitz, Elisa
Green, Myke R.
Babiker, Hani M.
author_facet Ong, Shawn Y.
Taverna, Josephine
Jokerst, Clint
Enzler, Thomas
Hammode, Emad
Rogowitz, Elisa
Green, Myke R.
Babiker, Hani M.
author_sort Ong, Shawn Y.
collection PubMed
description Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.
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spelling pubmed-46469962015-11-26 Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix Ong, Shawn Y. Taverna, Josephine Jokerst, Clint Enzler, Thomas Hammode, Emad Rogowitz, Elisa Green, Myke R. Babiker, Hani M. Case Rep Oncol Med Case Report Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option. Hindawi Publishing Corporation 2015 2015-11-03 /pmc/articles/PMC4646996/ /pubmed/26613055 http://dx.doi.org/10.1155/2015/212543 Text en Copyright © 2015 Shawn Y. Ong et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ong, Shawn Y.
Taverna, Josephine
Jokerst, Clint
Enzler, Thomas
Hammode, Emad
Rogowitz, Elisa
Green, Myke R.
Babiker, Hani M.
Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title_full Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title_fullStr Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title_full_unstemmed Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title_short Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix
title_sort prostate cancer-associated disseminated intravascular coagulation with excessive fibrinolysis treated with degarelix
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646996/
https://www.ncbi.nlm.nih.gov/pubmed/26613055
http://dx.doi.org/10.1155/2015/212543
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