Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary c...

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Detalles Bibliográficos
Autores principales: Sala-Rabanal, Monica, Yurtsever, Zeynep, Berry, Kayla N., Brett, Tom J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647060/
https://www.ncbi.nlm.nih.gov/pubmed/26612971
http://dx.doi.org/10.1155/2015/497387
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author Sala-Rabanal, Monica
Yurtsever, Zeynep
Berry, Kayla N.
Brett, Tom J.
author_facet Sala-Rabanal, Monica
Yurtsever, Zeynep
Berry, Kayla N.
Brett, Tom J.
author_sort Sala-Rabanal, Monica
collection PubMed
description Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases.
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spelling pubmed-46470602015-11-26 Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases Sala-Rabanal, Monica Yurtsever, Zeynep Berry, Kayla N. Brett, Tom J. Mediators Inflamm Review Article Chloride transport proteins play critical roles in inflammatory airway diseases, contributing to the detrimental aspects of mucus overproduction, mucus secretion, and airway constriction. However, they also play crucial roles in contributing to the innate immune properties of mucus and mucociliary clearance. In this review, we focus on the emerging novel roles for a chloride channel regulator (CLCA1), a calcium-activated chloride channel (TMEM16A), and two chloride exchangers (SLC26A4/pendrin and SLC26A9) in chronic inflammatory airway diseases. Hindawi Publishing Corporation 2015 2015-11-03 /pmc/articles/PMC4647060/ /pubmed/26612971 http://dx.doi.org/10.1155/2015/497387 Text en Copyright © 2015 Monica Sala-Rabanal et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sala-Rabanal, Monica
Yurtsever, Zeynep
Berry, Kayla N.
Brett, Tom J.
Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title_full Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title_fullStr Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title_full_unstemmed Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title_short Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases
title_sort novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647060/
https://www.ncbi.nlm.nih.gov/pubmed/26612971
http://dx.doi.org/10.1155/2015/497387
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