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The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study

The risk of active tuberculosis (TB) in patients with dermatomyositis (DM) is poorly understood. The cohort study aimed to investigate the association between DM and the risk of active TB disease. We conducted a population based study on 4,958 patients with newly diagnosed DM and 19,832 matched cont...

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Autores principales: Wu, Ping-Hsun, Lin, Yi-Ting, Yang, Yi-Hsin, Lin, Yu-Chih, Lin, Yi-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647179/
https://www.ncbi.nlm.nih.gov/pubmed/26573418
http://dx.doi.org/10.1038/srep16303
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author Wu, Ping-Hsun
Lin, Yi-Ting
Yang, Yi-Hsin
Lin, Yu-Chih
Lin, Yi-Ching
author_facet Wu, Ping-Hsun
Lin, Yi-Ting
Yang, Yi-Hsin
Lin, Yu-Chih
Lin, Yi-Ching
author_sort Wu, Ping-Hsun
collection PubMed
description The risk of active tuberculosis (TB) in patients with dermatomyositis (DM) is poorly understood. The cohort study aimed to investigate the association between DM and the risk of active TB disease. We conducted a population based study on 4,958 patients with newly diagnosed DM and 19,832 matched controls according to age, sex, and index date between 1998 and 2008. The hazard ratios (HRs) and cumulative incidences of active TB disease between DM patients and controls were analyzed. During the study period, a total of 85 (1.7%) DM patients developed active TB disease, which was significantly higher than that of non-DM patients (0.64%). The incidence rate of active TB disease was higher among DM patients than controls (incidence rate ratio 2.95; 95% confidence interval [CI], 2.24 to 3.88). The Cox regression model demonstrated significantly higher active TB disease rate among DM patients compared with controls (adjusted HR, 2.64; 95% CI, 1.97 to 3.54; p < 0.001) after adjusting for age, sex, and underlying medical disorders. The most significant risk factors for developing active TB included male sex, diabetes mellitus comorbidity, and use of corticosteroids and azathioprine in DM patients. In conclusion, DM patients are at a greater risk for active TB disease.
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spelling pubmed-46471792015-11-23 The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study Wu, Ping-Hsun Lin, Yi-Ting Yang, Yi-Hsin Lin, Yu-Chih Lin, Yi-Ching Sci Rep Article The risk of active tuberculosis (TB) in patients with dermatomyositis (DM) is poorly understood. The cohort study aimed to investigate the association between DM and the risk of active TB disease. We conducted a population based study on 4,958 patients with newly diagnosed DM and 19,832 matched controls according to age, sex, and index date between 1998 and 2008. The hazard ratios (HRs) and cumulative incidences of active TB disease between DM patients and controls were analyzed. During the study period, a total of 85 (1.7%) DM patients developed active TB disease, which was significantly higher than that of non-DM patients (0.64%). The incidence rate of active TB disease was higher among DM patients than controls (incidence rate ratio 2.95; 95% confidence interval [CI], 2.24 to 3.88). The Cox regression model demonstrated significantly higher active TB disease rate among DM patients compared with controls (adjusted HR, 2.64; 95% CI, 1.97 to 3.54; p < 0.001) after adjusting for age, sex, and underlying medical disorders. The most significant risk factors for developing active TB included male sex, diabetes mellitus comorbidity, and use of corticosteroids and azathioprine in DM patients. In conclusion, DM patients are at a greater risk for active TB disease. Nature Publishing Group 2015-11-17 /pmc/articles/PMC4647179/ /pubmed/26573418 http://dx.doi.org/10.1038/srep16303 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wu, Ping-Hsun
Lin, Yi-Ting
Yang, Yi-Hsin
Lin, Yu-Chih
Lin, Yi-Ching
The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title_full The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title_fullStr The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title_full_unstemmed The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title_short The increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
title_sort increased risk of active tuberculosis disease in patients with dermatomyositis – a nationwide retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647179/
https://www.ncbi.nlm.nih.gov/pubmed/26573418
http://dx.doi.org/10.1038/srep16303
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