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Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647215/ https://www.ncbi.nlm.nih.gov/pubmed/26395494 http://dx.doi.org/10.1242/dev.127209 |
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author | Weng, Ruifen Cohen, Stephen M. |
author_facet | Weng, Ruifen Cohen, Stephen M. |
author_sort | Weng, Ruifen |
collection | PubMed |
description | Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain. |
format | Online Article Text |
id | pubmed-4647215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Company of Biologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-46472152015-12-01 Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA Weng, Ruifen Cohen, Stephen M. Development Research Article Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain. The Company of Biologists 2015-11-01 /pmc/articles/PMC4647215/ /pubmed/26395494 http://dx.doi.org/10.1242/dev.127209 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Weng, Ruifen Cohen, Stephen M. Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title | Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title_full | Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title_fullStr | Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title_full_unstemmed | Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title_short | Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA |
title_sort | control of drosophila type i and type ii central brain neuroblast proliferation by bantam microrna |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647215/ https://www.ncbi.nlm.nih.gov/pubmed/26395494 http://dx.doi.org/10.1242/dev.127209 |
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