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Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA

Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation...

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Detalles Bibliográficos
Autores principales: Weng, Ruifen, Cohen, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647215/
https://www.ncbi.nlm.nih.gov/pubmed/26395494
http://dx.doi.org/10.1242/dev.127209
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author Weng, Ruifen
Cohen, Stephen M.
author_facet Weng, Ruifen
Cohen, Stephen M.
author_sort Weng, Ruifen
collection PubMed
description Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.
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spelling pubmed-46472152015-12-01 Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA Weng, Ruifen Cohen, Stephen M. Development Research Article Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain. The Company of Biologists 2015-11-01 /pmc/articles/PMC4647215/ /pubmed/26395494 http://dx.doi.org/10.1242/dev.127209 Text en © 2015. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Weng, Ruifen
Cohen, Stephen M.
Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title_full Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title_fullStr Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title_full_unstemmed Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title_short Control of Drosophila Type I and Type II central brain neuroblast proliferation by bantam microRNA
title_sort control of drosophila type i and type ii central brain neuroblast proliferation by bantam microrna
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647215/
https://www.ncbi.nlm.nih.gov/pubmed/26395494
http://dx.doi.org/10.1242/dev.127209
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