The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during viral infection. We find that, at high concentrations, T-bet induced expressi...

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Detalles Bibliográficos
Autores principales: Dominguez, Claudia X., Amezquita, Robert A., Guan, Tianxia, Marshall, Heather D., Joshi, Nikhil S., Kleinstein, Steven H., Kaech, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647261/
https://www.ncbi.nlm.nih.gov/pubmed/26503446
http://dx.doi.org/10.1084/jem.20150186

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