Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance

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Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors within the tumor microenvironment and eliciting tumor regression. We have found that Cish, a member of the suppressor of cytokine signaling (SOCS) family, is induced by TCR stimulation in CD8(+) T cells...

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Detalles Bibliográficos
Autores principales: Palmer, Douglas C., Guittard, Geoffrey C., Franco, Zulmarie, Crompton, Joseph G., Eil, Robert L., Patel, Shashank J., Ji, Yun, Van Panhuys, Nicholas, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Clever, David, Chichura, Anna, Roychoudhuri, Rahul, Varma, Rajat, Wang, Ena, Gattinoni, Luca, Marincola, Francesco M., Balagopalan, Lakshmi, Samelson, Lawrence E., Restifo, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647263/
https://www.ncbi.nlm.nih.gov/pubmed/26527801
http://dx.doi.org/10.1084/jem.20150304
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