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T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model
BACKGROUND: Sepsis is a potentially fatal syndrome mediated by an early [e.g., tumor necrosis factor-alpha (TNF-α)] and late [high mobility group box-1 (HMGB-1)] proinflammatory cytokine response to infection. Sepsis-induced acute kidney injury (AKI) is associated with a high mortality. C-Fos/activa...
Autores principales: | Ishida, Mari, Ueki, Masaaki, Morishita, Jun, Ueno, Masaki, Shiozawa, Shunichi, Maekawa, Nobuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647501/ https://www.ncbi.nlm.nih.gov/pubmed/26579229 http://dx.doi.org/10.1186/s40560-015-0115-2 |
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