T-5224, a selective inhibitor of c-Fos/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model

BACKGROUND: Sepsis is a potentially fatal syndrome mediated by an early [e.g., tumor necrosis factor-alpha (TNF-α)] and late [high mobility group box-1 (HMGB-1)] proinflammatory cytokine response to infection. Sepsis-induced acute kidney injury (AKI) is associated with a high mortality. C-Fos/activa...

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Detalles Bibliográficos
Autores principales: Ishida, Mari, Ueki, Masaaki, Morishita, Jun, Ueno, Masaki, Shiozawa, Shunichi, Maekawa, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647501/
https://www.ncbi.nlm.nih.gov/pubmed/26579229
http://dx.doi.org/10.1186/s40560-015-0115-2

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