Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research Datalink

BACKGROUND: We conducted the first study to investigate post-diagnostic oral bisphosphonates use and colorectal cancer-specific mortality. METHODS: Colorectal cancer patients were identified from the National Cancer Data Repository (1998–2007) and linked to the UK Clinical Practice Research Datalink...

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Detalles Bibliográficos
Autores principales: Hicks, B M, Murray, L J, Hughes, C, Cardwell, C R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647537/
https://www.ncbi.nlm.nih.gov/pubmed/25989268
http://dx.doi.org/10.1038/bjc.2015.152
Descripción
Sumario:BACKGROUND: We conducted the first study to investigate post-diagnostic oral bisphosphonates use and colorectal cancer-specific mortality. METHODS: Colorectal cancer patients were identified from the National Cancer Data Repository (1998–2007) and linked to the UK Clinical Practice Research Datalink, providing prescription records, and Office of National Statistics mortality data. Time-dependent Cox regression models investigated colorectal cancer-specific mortality in post-diagnostic bisphosphonate users. RESULTS: Overall, in 4791 colorectal cancer patients, there was no evidence of an association between bisphosphonate use and colorectal cancer-specific mortality (adjusted hazard ratio=1.11; 95% confidence interval 0.80, 1.54) or with drug frequency or type. CONCLUSIONS: In this novel population-based cohort study, post-diagnostic bisphosphonate use was not associated with longer rates of colorectal cancer survival.

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