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Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer

BACKGROUND: Survival rates in lung cancer in England are significantly lower than in many similar countries. A range of Be Clear on Cancer (BCOC) campaigns have been conducted targeting lung cancer and found to improve the proportion of diagnoses at the early stage of disease. This paper considers t...

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Autores principales: Hinde, S, McKenna, C, Whyte, S, Peake, M D, Callister, M E J, Rogers, T, Sculpher, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647547/
https://www.ncbi.nlm.nih.gov/pubmed/26010412
http://dx.doi.org/10.1038/bjc.2015.167
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author Hinde, S
McKenna, C
Whyte, S
Peake, M D
Callister, M E J
Rogers, T
Sculpher, M
author_facet Hinde, S
McKenna, C
Whyte, S
Peake, M D
Callister, M E J
Rogers, T
Sculpher, M
author_sort Hinde, S
collection PubMed
description BACKGROUND: Survival rates in lung cancer in England are significantly lower than in many similar countries. A range of Be Clear on Cancer (BCOC) campaigns have been conducted targeting lung cancer and found to improve the proportion of diagnoses at the early stage of disease. This paper considers the cost-effectiveness of such campaigns, evaluating the effect of both the regional and national BCOC campaigns on the stage distribution of non-small-cell lung cancer (NSCLC) at diagnosis. METHODS: A natural history model of NSCLC was developed using incidence data, data elicited from clinical experts and model calibration techniques. This structure is used to consider the lifetime cost and quality-adjusted survival implications of the early awareness campaigns. Incremental cost-effectiveness ratios (ICERs) in terms of additional costs per quality-adjusted life-years (QALYs) gained are presented. Two scenario analyses were conducted to investigate the role of changes in the ‘worried-well' population and the route of diagnosis that might occur as a result of the campaigns. RESULTS: The base-case theoretical model found the regional and national early awareness campaigns to be associated with QALY gains of 289 and 178 QALYs and ICERs of £13 660 and £18 173 per QALY gained, respectively. The scenarios found that increases in the ‘worried-well' population may impact the cost-effectiveness conclusions. CONCLUSIONS: Subject to the available evidence, the analysis suggests that early awareness campaigns in lung cancer have the potential to be cost-effective. However, significant additional research is required to address many of the limitations of this study. In addition, the estimated natural history model presents previously unavailable estimates of the prevalence and rate of disease progression in the undiagnosed population.
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spelling pubmed-46475472015-11-17 Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer Hinde, S McKenna, C Whyte, S Peake, M D Callister, M E J Rogers, T Sculpher, M Br J Cancer Epidemiology BACKGROUND: Survival rates in lung cancer in England are significantly lower than in many similar countries. A range of Be Clear on Cancer (BCOC) campaigns have been conducted targeting lung cancer and found to improve the proportion of diagnoses at the early stage of disease. This paper considers the cost-effectiveness of such campaigns, evaluating the effect of both the regional and national BCOC campaigns on the stage distribution of non-small-cell lung cancer (NSCLC) at diagnosis. METHODS: A natural history model of NSCLC was developed using incidence data, data elicited from clinical experts and model calibration techniques. This structure is used to consider the lifetime cost and quality-adjusted survival implications of the early awareness campaigns. Incremental cost-effectiveness ratios (ICERs) in terms of additional costs per quality-adjusted life-years (QALYs) gained are presented. Two scenario analyses were conducted to investigate the role of changes in the ‘worried-well' population and the route of diagnosis that might occur as a result of the campaigns. RESULTS: The base-case theoretical model found the regional and national early awareness campaigns to be associated with QALY gains of 289 and 178 QALYs and ICERs of £13 660 and £18 173 per QALY gained, respectively. The scenarios found that increases in the ‘worried-well' population may impact the cost-effectiveness conclusions. CONCLUSIONS: Subject to the available evidence, the analysis suggests that early awareness campaigns in lung cancer have the potential to be cost-effective. However, significant additional research is required to address many of the limitations of this study. In addition, the estimated natural history model presents previously unavailable estimates of the prevalence and rate of disease progression in the undiagnosed population. Nature Publishing Group 2015-06-30 2015-05-26 /pmc/articles/PMC4647547/ /pubmed/26010412 http://dx.doi.org/10.1038/bjc.2015.167 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 3.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Epidemiology
Hinde, S
McKenna, C
Whyte, S
Peake, M D
Callister, M E J
Rogers, T
Sculpher, M
Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title_full Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title_fullStr Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title_full_unstemmed Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title_short Modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
title_sort modelling the cost-effectiveness of public awareness campaigns for the early detection of non-small-cell lung cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647547/
https://www.ncbi.nlm.nih.gov/pubmed/26010412
http://dx.doi.org/10.1038/bjc.2015.167
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