Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers

Somatic mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are the most common noncoding mutations in cancer. They are thought to activate telomerase, contributing to proliferative immortality, but the molecular events driving TERT activation are largely unknown. We ob...

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Detalles Bibliográficos
Autores principales: Stern, Josh Lewis, Theodorescu, Dan, Vogelstein, Bert, Papadopoulos, Nickolas, Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647555/
https://www.ncbi.nlm.nih.gov/pubmed/26515115
http://dx.doi.org/10.1101/gad.269498.115

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