A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we charact...

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Detalles Bibliográficos
Autores principales: Brien, Gerard L., Healy, Evan, Jerman, Emilia, Conway, Eric, Fadda, Elisa, O'Donovan, Darragh, Krivtsov, Andrei V., Rice, Alan M., Kearney, Conor J., Flaus, Andrew, McDade, Simon S., Martin, Seamus J., McLysaght, Aoife, O'Connell, David J., Armstrong, Scott A., Bracken, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647557/
https://www.ncbi.nlm.nih.gov/pubmed/26494712
http://dx.doi.org/10.1101/gad.267930.115

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