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LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

The host chromatin-binding factor LEDGF/p75 interacts with HIV-1 integrase and directs integration to active transcription units. To understand how LEDGF/p75 recognizes transcription units, we sequenced 1 million HIV-1 integration sites isolated from cultured HEK293T cells. Analysis of integration s...

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Detalles Bibliográficos
Autores principales:	Singh, Parmit Kumar, Plumb, Matthew R., Ferris, Andrea L., Iben, James R., Wu, Xiaolin, Fadel, Hind J., Luke, Brian T., Esnault, Caroline, Poeschla, Eric M., Hughes, Stephen H., Kvaratskhelia, Mamuka, Levin, Henry L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647561/ https://www.ncbi.nlm.nih.gov/pubmed/26545813 http://dx.doi.org/10.1101/gad.267609.115

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